Thursday, September 27, 2018

The Brain Nutrients and Depression: Presentation by A. Patrick Jonas, MD

The Brain, Nutrients and Depression.         A. Patrick Jonas, MD
Institute of Holistic Leadership September 27, 2018


The Brain. The last frontier?  Nutrient Power by William Walsh, PhD
Nutrients:  Food, supplements, vitamins, minerals, phytonutrients= nutraceuticals
Depression:  Definition(s)
           6 types: Undermethylation, Folate Deficiency, Copper Overload, Pyrrole Disorder, Toxic, Other
Neurons- cells that process signals at 200 mph.  100 B in the brain
           4-100 microns diameter.  Up to 4 inches in length. Act as tiny battery cells
           Long axon transmit electrochemical signal across synapse to other cell.
           1000 hair-like dendrites branching from the cell body, receiving chemical messages
           100 T receptors in average brain
Neurotransmitters: are made, packaged into vesicles, release into synapse, interact w/adjacent cell,      reuptake, death
Most psychiatric meds alter neurotransmitter activity at synapses.  e.g., SSRI’s disable transporters
           Top six biochemical imbalances in brain disorders
           Copper overload, Vitamin B-6 Deficiency, Zinc deficiency, Methyl/folate imbalances, Oxidative stress overload, Amino acid imbalances
Methylation Pathway Model by Amy Yasko, PhD - See Handout
Spectracell Depression Wheel --See Handout
Epigenetics:  DNA wraps around histones which have “tails”, where chemicals may adhere.   Methyl groups- tighten DNA wrap around histone and decrease expression of genes
           Delivered by SAMe to histones
Acetyl groups- loosen DNA wrap around histone and increase gene expression
           Delivered by acetyl coenzyme A to histones, delivers hi energy acetyl groups to mitochondria for processing in the citric acid cycle.
Neurotransmitter Transporter Proteins.  Methyl vs Acetyl for histone tails.  Gene expression of serotonin, dopamine and norepinephrine transporters dependent on M vs. A competition.  E.g.,histone methylation promoters are natural SSRI’s
Nutrient therapy and epigenetics:  Methionine and SAMe, Folic Acid, Niacin (B-3), other nutrients.
Epigenetic disorders:  Autism, Depression, Schizoaffective Disorder, Paranoid Schizophrenia, OCD, ASPD, Anorexia, OCP
Transgenerational Epigenetic Inheritance
The Clinical Process hx and pe, labs, diagnosis, treatment, aftercare
Nutrients and Neurotransmitters
                                 Increased Activity                                 Decreased Activity

Response times vary
           Pyrrole Disorder
           Zinc Deficiency
           Copper Overload
Toxic Metal Overload
Depression:  Undermethylation, folate deficiency, copper overload, pyrrole disorder, toxic, other
Schizophrenia:   overmethylated, undermethylated, pyrrole disorder
Autism:  Zinc deficiency, copper overload, B-6 Deficiency, Elevated toxic metals, oxidative stress, undermethylation
Behavioral Disorders and ADHD (94% with chemical imbalances):  Abnormal copper and zinc levels in violent persons, copper and zinc and Vitamin B-6

Tuesday, September 25, 2018

Crooked Trails: Interview and Discussion with Author Sandra Miller, MD

Sandra Miller, MD has created another medical adventure novel featuring Abigail Willmore, MD.  The second novel in this series (number 3 is almost complete) continues the story of Dr Willmore, who was successful at the Grand Canyon Clinic in Only Rock is Real, the inaugural book for Dr. Miller.  Read my post about the first novel by clicking here.  (including a link to the interview recording on the Dr. Synonymous Show).

Now we find Abby (Dr. Willmore) agreeing to practice in the expanding Yellowstone National Park Clinic for the summer.  Dr Miller's vocabulary is up to the task of writing about the breathtaking scenery, from the heavens to the glaciers and volcanoes to the sunrises and sunsets to the tattoo of a snake, which she calls "Bitey", on the arm of the clinic nurse.  As a retired Family Physician and educator, her medical vocabulary adds to the sizzle when she describes human relationships, illness, bleeding, nausea, infection, immunizations, medical office processes, delusion, stalking, sexuality, professionalism and sexual assault.

If you also are curious about Yellowstone National Park and dinosaurs in Montana, showcased in a medical thriller, get this book.  If you also want to hear the author discuss how she creates her work, listen to this and the previous interview on her first book.

We'll discuss many of these aspects of her book and her general writing style in the interview which will be broadcast on the internet on The Dr. Synonymous Show on Blogtalk Radio Monday October 1, 2018 at 9:30 PM Eastern.  At that time and for years thereafter you can:

Click here for interview on The Dr. Synonymous Show

Sunday, September 23, 2018


Malaise is defined as "a condition of general bodily weakness or discomfort, often marking the onset of a disease. a vague or unfocused feeling of mental uneasiness, lethargy, or discomfort."

I love the word.  I even appreciate experiencing it every year or two for 34 - 48 hours.  I have it now.
With myalgias - muscle pain.  Everywhere.  Similar to the first day of the flu.  But without the mucous in the head and lungs with the intense cough of the flu, fortunately.

The feelings of malaise and myalgias are caused by the white blood cells bursting and allowing interferon to float through the circulation.  Maybe it's part of the grand design to keep us away from other people when we're infected, to minimize the spread of contagious microbes.