The Brain Nutrients and Depression: Presentation by A. Patrick Jonas, MD

The Brain, Nutrients and Depression.         A. Patrick Jonas, MD

Institute of Holistic Leadership September 27, 2018

Outline

The Brain. The last frontier?  Nutrient Power by William Walsh, PhD

Nutrients:  Food, supplements, vitamins, minerals, phytonutrients= nutraceuticals

Depression:  Definition(s)

           6 types: Undermethylation, Folate Deficiency, Copper Overload, Pyrrole Disorder, Toxic, Other

Neurons- cells that process signals at 200 mph.  100 B in the brain

           4-100 microns diameter.  Up to 4 inches in length. Act as tiny battery cells

           Long axon transmit electrochemical signal across synapse to other cell.

           1000 hair-like dendrites branching from the cell body, receiving chemical messages

           100 T receptors in average brain

Neurotransmitters: are made, packaged into vesicles, release into synapse, interact w/adjacent cell,      reuptake, death

Most psychiatric meds alter neurotransmitter activity at synapses.  e.g., SSRI’s disable transporters

Nutrients

           Top six biochemical imbalances in brain disorders

           Copper overload, Vitamin B-6 Deficiency, Zinc deficiency, Methyl/folate imbalances, Oxidative stress overload, Amino acid imbalances

Methylation Pathway Model by Amy Yasko, PhD - See Handout

Spectracell Depression Wheel --See Handout

Epigenetics:  DNA wraps around histones which have “tails”, where chemicals may adhere.   Methyl groups- tighten DNA wrap around histone and decrease expression of genes

           Delivered by SAMe to histones

Acetyl groups- loosen DNA wrap around histone and increase gene expression

           Delivered by acetyl coenzyme A to histones, delivers hi energy acetyl groups to mitochondria for processing in the citric acid cycle.

Neurotransmitter Transporter Proteins.  Methyl vs Acetyl for histone tails.  Gene expression of serotonin, dopamine and norepinephrine transporters dependent on M vs. A competition.  E.g.,histone methylation promoters are natural SSRI’s

Nutrient therapy and epigenetics:  Methionine and SAMe, Folic Acid, Niacin (B-3), other nutrients.

Epigenetic disorders:  Autism, Depression, Schizoaffective Disorder, Paranoid Schizophrenia, OCD, ASPD, Anorexia, OCP

Transgenerational Epigenetic Inheritance

The Clinical Process hx and pe, labs, diagnosis, treatment, aftercare

Nutrients and Neurotransmitters

                                 Increased Activity                                 Decreased Activity

Serotonin

Dopamine

Norepinephrine

NMDA

GABA

Response times vary

           Pyrrole Disorder

           Zinc Deficiency

           Copper Overload

Overmethylation

Undermethylation

Toxic Metal Overload

Depression:  Undermethylation, folate deficiency, copper overload, pyrrole disorder, toxic, other

Schizophrenia:   overmethylated, undermethylated, pyrrole disorder

Autism:  Zinc deficiency, copper overload, B-6 Deficiency, Elevated toxic metals, oxidative stress, undermethylation

Behavioral Disorders and ADHD (94% with chemical imbalances):  Abnormal copper and zinc levels in violent persons, copper and zinc and Vitamin B-6

Crooked Trails: Interview and Discussion with Author Sandra Miller, MD

Sandra Miller, MD has created another medical adventure novel featuring Abigail Willmore, MD.  The second novel in this series (number 3 is almost complete) continues the story of Dr Willmore, who was successful at the Grand Canyon Clinic in Only Rock is Real, the inaugural book for Dr. Miller.  Read my post about the first novel by clicking here.  (including a link to the interview recording on the Dr. Synonymous Show).

Now we find Abby (Dr. Willmore) agreeing to practice in the expanding Yellowstone National Park Clinic for the summer.  Dr Miller's vocabulary is up to the task of writing about the breathtaking scenery, from the heavens to the glaciers and volcanoes to the sunrises and sunsets to the tattoo of a snake, which she calls "Bitey", on the arm of the clinic nurse.  As a retired Family Physician and educator, her medical vocabulary adds to the sizzle when she describes human relationships, illness, bleeding, nausea, infection, immunizations, medical office processes, delusion, stalking, sexuality, professionalism and sexual assault.

If you also are curious about Yellowstone National Park and dinosaurs in Montana, showcased in a medical thriller, get this book.  If you also want to hear the author discuss how she creates her work, listen to this and the previous interview on her first book.

We'll discuss many of these aspects of her book and her general writing style in the interview which will be broadcast on the internet on The Dr. Synonymous Show on Blogtalk Radio Monday October 1, 2018 at 9:30 PM Eastern.  At that time and for years thereafter you can:

Click here for interview on The Dr. Synonymous Show

Malaise

Malaise is defined as "a condition of general bodily weakness or discomfort, often marking the onset of a disease. a vague or unfocused feeling of mental uneasiness, lethargy, or discomfort."

I love the word.  I even appreciate experiencing it every year or two for 34 - 48 hours.  I have it now.
With myalgias - muscle pain.  Everywhere.  Similar to the first day of the flu.  But without the mucous in the head and lungs with the intense cough of the flu, fortunately.

The feelings of malaise and myalgias are caused by the white blood cells bursting and allowing interferon to float through the circulation.  Maybe it's part of the grand design to keep us away from other people when we're infected, to minimize the spread of contagious microbes.

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